EVALUATION OF THE BINDING AND SUSPENDING PROPERTIES OF BAGGASE-DERIVED METHYLCELLULOSE
- Project Research
- 1-5 Chapters
- Abstract : Available
- Table of Content: Available
- Reference Style: APA
- Recommended for : Student Researchers
- NGN 3000
ABSTRACT
Sourcing of raw materials for use in pharmaceutical industries is a continuing challenge. Excipients, which form the bulk of a dosage form, are derived either from natural sources or synthesized wholly or semi-synthesized. The absence of an ideal excipient material continues to spur research towards identifying and developing excipients from various sources. One of such potential sources is sugar cane bagasse which is an abundant agricultural waste. This work, investigated the properties of derived methylcellulose from sugarcane and evaluated its suitability as a pharmaceutical grade excipient. Methylcellulose was derived from locally sourced bagasse in Zaria, Nigeria by standard extraction procedures. The bagasse-derived methylcellulose (BDMC) was characterised by studying its physicochemical properties, namely moisture content, particle size distribution, shape and viscosity. The stability and flow properties of the powder were also investigated. To confirm the quality of the BDMC, the measured properties were compared with those of a highgrade standard methylcellulose (Methocel® ). To ascertain its suitability as an excipient, its effectiveness as a binder in a large dose formulation was studied using 500 mg paracetamol tablets. Its use as a suspending agent was investigated in co-trimoxazole and metronidazole suspensions. The physical properties such as mean particle size, size distribution, shape, and viscosity of BDMC compared favourably with those of Methocel® . The disintegration time, crushing strength, friability and dissolution profiles of tablets formulated with BDMC as binder were very similar to those prepared with Methocel® . BDMC and Methocel® containing suspensions exhibited pseudoplastic flow behaviour as indicated by their reduced viscosity values. The redispersibility study revealed that, both BDMC and Methocel® influenced the intrinsic vii properties of the active constituents in the suspension formulations. Suspensions made with Methocel® were more flocculated than those formulated with BDMC. Results of the various parameters studied indicated that concentration of 2 per cent of the BDMC can be used as a binder to produce pharmaceutical grade tablets. It is also a suitable suspending agent for producing flocculated, easily dispersible suspensions of indiffusible pharmaceutical active ingredients such as co-trimoxazole and metronidazole.
Related Project Materials
EFFECTS OF DRUG ABUSE ON SENIOR SECONDARY SCHOOL STUDENTS’ ATTITUDE TOWARDS LEARNING: A CASE OF STUDY OF SECONDARY SCHOOL STUDENTS IN IKENNE LOCAL GOVERNMENT AREA OF OGUN STATE
ABSTRACT
Drug abuse, equally known as substance abuse, is the use of a substance usually for non-medical purposes which...
THE INFLUENCE OF SOCIAL TRENDS ON BUSINESS OPERATIONS
ABSTRACT: THE INFLUENCE OF SOCIAL TRENDS ON BUSINESS OPERATIONS
The study’s obje...
OBESITY AND IT IMPLICATIONS AMONG RURAL ADULT
BACKGROUND OF THE STUDY
In affluent societies, obesity is the most common nutritional disorder. Obesity...
FACTORS RESPONSIBLE FOR THE CONTRIBUTIONS OF SMALL AND MEDIUM SCALE BUSINESS TO ECONOMIC DEVELOPMENT (A CASE STUDY OF OIL FIELD TRANSPORT)
BACKROUND OF THE STUDY
The economy of Nigeria was mostly based on agriculture for a long time until oil...
DESIGN AND IMPLEMENTATION OF AUTOMATED LIBRARY SYSTEM
STATEMENT OF PROBLEM
In human endeavors, there are a lot of developments, researches, and discoveries, which result in m...
APPRAISAL OF THE QUALITY OF POLITICAL COMMUNICATION DURING 2015 GENERAL ELECTIONS
BACKGROUND TO THE STUDY
Politi...
DRUG ABUSE AND MENTAL STABILITY AS PREDICTOR OF STUDY HABIT OF UNDERGRADUATES
ABSTRACT
The study examines drug abuse and mental stability as predictors of study habit of undergraduates...
HUMAN CAPITAL DEVELOPMENT AND ORGANIZATIONAL PERFORMANCE
ABSTRACT
This study examined the relationship between human capital development and organizational...
YOUTH EMPOWERMENT AS A STRATEGY FOR REDUCING CRIME IN NIGERIA
BACKGROUND OF THE STUDY
Youth empowerment involve build the capacity of young people and motivating them to take respons...
BEAM DISCOVERY AND TRACKING FOR MOBILE MIMO
ABSTRACT
The real-time applications and the IoT promote the need for a newer idle spectrum to support the required high traffic. This pus...
